Description

n-Benzyloxycarbonylglycine Thioamide is a protected amino acid derivative, specifically a thioamide analog of Z-glycine. This compound serves as a versatile and critical building block in organic synthesis, particularly for the preparation of modified peptides and heterocyclic compounds. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of novel bioactive molecules.

Application

• Peptidomimetic Synthesis: A key intermediate for introducing thioamide bonds into peptide backbones, altering stability and biological activity.
• Heterocyclic Chemistry: Used in the construction of thiazole, thiadiazole, and other nitrogen-sulfur heterocycles with potential pharmaceutical applications.
• Medicinal Chemistry Research: Serves as a scaffold for developing enzyme inhibitors, receptor modulators, and other pharmacologically active agents.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Useful for creating labeled or modified peptides to study protein-protein interactions and enzymatic processes.

Basic Information

Product Name	n-Benzyloxycarbonylglycine Thioamide
CAS No.	49548-40-5
Molecular Formula	C10H12N2O2S
Molecular Weight	224.28 g/mol
Synonyms	Z-Glycine Thioamide; N-Carbobenzoxyglycine Thioamide; (Benzyloxycarbonyl)glycine Thioamide; Cbz-Glycine Thioamide; Nα-Carbobenzyloxyglycine Thioamide; N-(Benzyloxycarbonyl)glycinethioamide; Glycine, N-[(phenylmethoxy)carbonyl]-, thioamide
EINECS	Contact for details

Quality Control

Our n-Benzyloxycarbonylglycine Thioamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.