Description

Ddz-Cys(Tbuthio)-Oh is a specialized, protected cysteine derivative used as a critical building block in peptide synthesis. This compound matters for its role in introducing the thiol-containing cysteine residue into peptide chains under controlled conditions, preventing unwanted side reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, peptide-based diagnostics, and biochemical research where precise molecular assembly is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the sequential construction of complex peptides.
• Solution-Phase Peptide Synthesis: For the synthesis of shorter peptide sequences or peptide fragments in solution.
• Bioconjugation: The tert-butylthio (Tbuthio) protecting group allows for selective deprotection, enabling site-specific conjugation to other molecules, such as fluorophores or drug payloads.
• Research & Development: Used in academic and industrial R&D for exploring protein structure-function relationships and novel peptide therapeutics.
• Production of Cysteine-Containing Peptide APIs: A vital raw material in the cGMP-compliant manufacturing of active pharmaceutical ingredients (APIs) that contain cysteine.

Basic Information

Product Name	Ddz-Cys(Tbuthio)-Oh
CAS No.	47592-85-8
Molecular Formula	C16H23NO5S2
Molecular Weight	381.49 g/mol
Synonyms	N-Ddz-S-tert-butylthio-L-cysteine; N-[(2,4-Dimethoxyphenyl)methyl]-S-(tert-butylthio)-L-cysteine; Ddz-Cys(StBu)-OH; Fmoc-Cys(StBu)-OH precursor; N-2,4-Dimethoxybenzyl-S-tert-butylthio-L-cysteine; L-Cysteine, N-[(2,4-dimethoxyphenyl)methyl]-S-(1,1-dimethylethyl)thio-; Protected Cysteine Derivative; Amino Acid Building Block for SPPS
EINECS	Contact for details

Quality Control

Our Ddz-Cys(Tbuthio)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric purity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic nature, the container should be kept sealed in a desiccated environment to prevent moisture uptake, which can affect stability and performance in sensitive synthetic applications.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.