Description

Boc-D-Ser(Bzl)-Oh is a protected derivative of the non-natural D-serine amino acid, featuring tert-butyloxycarbonyl (Boc) and benzyl (Bzl) protecting groups. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing therapeutic peptides, protease inhibitors, and novel drug candidates where structural integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetic drugs.
• Protease Inhibitor Development: Used in constructing active site-directed inhibitors for enzymes like serine proteases.
• Antibiotic Research: Incorporated into the backbone of novel glycopeptide and lipopeptide antibiotics.
• Bioconjugation & Labeling: Serves as a modified amino acid for introducing functional handles or labels into bioactive peptides.
• Chemical Biology Probes: Utilized in synthesizing activity-based probes to study enzyme function and mechanism.
• Academic & R&D: A fundamental reagent for exploring peptide structure-activity relationships (SAR) and new synthetic methodologies.

Basic Information

Product Name	Boc-D-Ser(Bzl)-Oh
CAS No.	47173-80-8
Molecular Formula	C15H21NO5
Molecular Weight	295.33 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-benzyl-D-serine; Boc-O-benzyl-D-serine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(benzyloxy)propanoic acid; D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, O-(phenylmethyl)-; Boc-D-Ser(OBzl)-OH; Boc-D-Ser(Bn)-OH; N-Boc-O-benzyl-D-serine
EINECS	Contact for details

Quality Control

Our Boc-D-Ser(Bzl)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing purity, specific rotation, and impurity profiles is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Specific Rotation [α]20/D	-10.0° to -12.0° (c=1 in DMF)
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.