Description

()-trans-10-Hydroxynortriptyline is a specific stereoisomer of a nortriptyline metabolite, a compound of significant interest in pharmaceutical research and development. Its primary value lies in its role as a key reference standard and analytical intermediate for the study of metabolic pathways and drug activity. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and life sciences sectors, particularly those focused on neuropharmacology and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of nortriptyline and its metabolites in drug development and quality control.
• Metabolic Pathway Research: Serves as a critical tool in studying the biotransformation and pharmacokinetics of tricyclic antidepressant drugs.
• Analytical Method Development: Essential for developing and validating precise HPLC, LC-MS, or GC-MS methods in bioanalytical laboratories.
• Impurity Profiling: Acts as a characterized impurity standard to monitor and control the quality of active pharmaceutical ingredients (APIs).
• Preclinical and Clinical Studies: Utilized in research to understand drug efficacy, safety, and metabolic fate.
• Chemical Synthesis Intermediate: Can be used as a building block for the synthesis of more complex molecules or labeled analogs for tracer studies.

Basic Information

Product Name	()-trans-10-Hydroxynortriptyline
CAS No.	47132-16-1
Molecular Formula	C₁₉H₂₁NO
Molecular Weight	279.38 g/mol
Synonyms	(10R,11S)-10-Hydroxynortriptyline; 10-Hydroxynortriptyline (trans isomer); 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-, (10R,11S)-10-hydroxy-; trans-10-Hydroxynortriptyline; Nortriptyline metabolite; 10-OH-Nortriptyline (trans); E-10-Hydroxynortriptyline
EINECS	Contact for details

Quality Control

Our ()-trans-10-Hydroxynortriptyline is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards to meet the needs of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.