Description

7-Amino-3-Vinyl-3-Cephem-4-Carboxylic Acid tert-Butyl Ester is a key advanced pharmaceutical intermediate (API) in the synthesis of modern cephalosporin antibiotics. Its core value lies in providing the essential cephem nucleus with a reactive vinyl group and protected carboxylic acid, enabling efficient downstream chemical modifications to create potent antibacterial agents. This compound is critically needed by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on developing next-generation β-lactam antibiotics to combat resistant bacterial strains.

Application

• Primary Intermediate for the synthesis of third and fourth-generation cephalosporin antibiotics.
• Pharmaceutical R&D for creating novel β-lactam structures with enhanced antibacterial spectra.
• API Manufacturing as a building block in the commercial production of specific cephalosporin drugs.
• Chemical Research for studying structure-activity relationships (SAR) within the cephem class of compounds.
• Process Chemistry for developing and optimizing scalable synthetic routes to final antibiotic products.

Basic Information

Product Name	7-Amino-3-Vinyl-3-Cephem-4-Carboxylic Acid tert-Butyl Ester
CAS No.	46962-26-9
Molecular Formula	C14H20N2O4S
Molecular Weight	312.38 g/mol
Synonyms	(6R,7R)-7-Amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester; 7-ADCA tert-butyl ester vinyl derivative; 7-Amino-3-vinylceph-3-em-4-carboxylic acid tert-butyl ester; tert-Butyl 7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 3-Vinyl-7-ADCA tert-butyl ester; 7-AVCA tert-butyl ester
EINECS	Contact for details

Quality Control

Our 7-Amino-3-Vinyl-3-Cephem-4-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and compliance with stringent specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.