Description

n-Desmethylnefopam is a key pharmaceutical intermediate and metabolite of the centrally-acting analgesic, nefopam. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in the development of non-opioid pain management solutions and related analytical standards.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of nefopam and its related analogs.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical studies for pharmacokinetic and metabolic profiling.
• Analytical Research: Serves as a high-purity standard in HPLC, LC-MS, and other chromatographic methods for method development and validation.
• Pharmacological Studies: Employed in preclinical and clinical research to understand the metabolic pathways and activity of nefopam.
• Quality Control: Essential for pharmaceutical QC laboratories to identify and quantify impurities and degradation products in nefopam API and finished dosage forms.

Basic Information

Product Name	n-Desmethylnefopam
CAS No.	46868-19-3
Molecular Formula	C16H17NO
Molecular Weight	239.32 g/mol
Synonyms	Desmethylnefopam; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine-8-ol; 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocin-8-ol; Nefopam Metabolite; N-Desmethyl Nefopam; 1-Phenyl-5-methyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocin-8-ol; Benzoxazocine-8-ol, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-
EINECS	Contact for details

Quality Control

Our n-Desmethylnefopam is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances and residual solvents, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.