Description

5-Oxo-1-(Trifluoroacetyl)-L-Proline is a high-purity, protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in the trifluoroacetyl protecting group, which offers distinct reactivity and stability advantages for constructing complex peptide and peptidomimetic structures. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce modified proline residues with enhanced metabolic stability.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors targeting specific proteolytic enzymes.
• Bioconjugation: Acts as a specialized linker or handle for attaching payloads in antibody-drug conjugate (ADC) research.
• Chemical Biology Probes: Utilized in the creation of activity-based probes for studying enzyme function and mechanism.
• Agrochemical Research: Employed in the development of novel, bioactive compounds with specific chiral configurations.

Basic Information

Product Name	5-Oxo-1-(Trifluoroacetyl)-L-Proline
CAS No.	46383-56-6
Molecular Formula	C7H6F3NO4
Molecular Weight	225.12 g/mol
Synonyms	1-(Trifluoroacetyl)-5-oxo-L-proline; (S)-1-(Trifluoroacetyl)-5-oxopyrrolidine-2-carboxylic Acid; L-Proline, 5-oxo-1-(trifluoroacetyl)-; 5-Oxo-N-(trifluoroacetyl)-L-proline; 5-Oxo-1-trifluoroacetyl-L-proline; 5-Oxo-1-(trifluoroacetyl)proline; TFA-5-oxo-L-Pro-OH; N-TFA-5-oxo-L-proline
EINECS	Contact for details

Quality Control

Our 5-Oxo-1-(Trifluoroacetyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.