Description

5-Oxo-1-(Trifluoroacetyl)Proline is a high-value, non-proteinogenic proline derivative characterized by its trifluoroacetyl-protected amine and lactam functionalities. This compound matters as a versatile and critical advanced pharmaceutical intermediate (API intermediate) and a specialized building block in organic synthesis, enabling the introduction of constrained, fluorinated motifs. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel bioactive molecules and peptidomimetics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting proteases or requiring conformationally restricted peptide backbones.
• Peptidomimetic Research: Used to create modified peptide analogs with enhanced metabolic stability and binding affinity by incorporating a fluorinated, rigid proline scaffold.
• Agrochemical Synthesis: Serves as a precursor for developing novel herbicides or pesticides with fluorinated active ingredients for improved efficacy and environmental profile.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes or inhibitors for studying enzyme function and biological pathways.
• Material Science: Potential monomer or modifier for creating specialized polymers with unique surface properties or stability due to the fluorine content.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis projects and scale-up development for client programs.

Basic Information

Product Name	5-Oxo-1-(Trifluoroacetyl)Proline
CAS No.	46383-55-5
Molecular Formula	C7H6F3NO3
Molecular Weight	209.12 g/mol
Synonyms	1-(Trifluoroacetyl)-5-oxoproline; 1-(Trifluoroacetyl)-5-pyrrolidone-2-carboxylic Acid; 5-Oxo-1-(trifluoroacetyl)-L-proline; 5-Oxo-1-(trifluoroacetyl)pyrrolidine-2-carboxylic Acid; N-Trifluoroacetyl-5-oxoproline; (S)-1-(Trifluoroacetyl)-5-oxopyrrolidine-2-carboxylic Acid; 2-Pyrrolidinecarboxylic acid, 1-(trifluoroacetyl)-5-oxo-; 5-Oxo-N-(trifluoroacetyl)proline
EINECS	Contact for details

Quality Control

Our 5-Oxo-1-(Trifluoroacetyl)Proline is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and chiral purity where applicable. Our quality commitment supports its use as a reliable intermediate in GMP and non-GMP synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (if applicable)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.