Description

n-Acetyl-D3-S-(2-Ethoxycarbonylethyl-1-Methyl)-L-Cysteine is a deuterated, S-substituted cysteine derivative, specifically designed for advanced research and analytical applications. This compound is of significant value as a stable isotope-labeled internal standard for precise quantification in mass spectrometry-based metabolomic and proteomic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in biomarker discovery, drug metabolism and pharmacokinetics (DMPK) research, and toxicology studies.

Application

• As a deuterium-labeled internal standard (IS) for the accurate LC-MS/MS quantification of related cysteine adducts in biological matrices.
• In biomarker research for studying exposure to specific chemicals or metabolic pathways involving S-substituted cysteine derivatives.
• For drug metabolism studies to track and quantify metabolites formed via conjugation pathways.
• Use in proteomics and metabolomics to enhance data accuracy and reliability through isotope dilution techniques.
• As a critical reference material in toxicological and forensic analysis for identifying specific exposure markers.
• In the development and validation of highly sensitive analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	n-Acetyl-D3-S-(2-Ethoxycarbonylethyl-1-Methyl)-L-Cysteine
CAS No.	45215-04-1
Molecular Formula	C₁₁H₁₅D₃NO₅S
Molecular Weight	277.34 g/mol (approx.)
Synonyms	N-Acetyl-S-(2-ethoxycarbonyl-1-methylethyl)-L-cysteine-d3; N-Acetyl-S-(2-carbethoxy-1-methylethyl)-L-cysteine-d3; N-Acetyl-S-(2-ethoxycarbonyl-1-methylpropyl)-L-cysteine-d3; Deuterated N-Acetyl-S-(2-ethoxycarbonylethyl-1-methyl)-L-cysteine; N-Acetyl-3-[(2-ethoxy-2-oxo-1-methylpropyl)thio]-L-alanine-d3; Acetyl-D3-S-(2-Ethoxycarbonylethyl-1-Methyl)cysteine; Internal Standard for Cysteine Adducts-d3
EINECS	Contact for details

Quality Control

Our deuterated analytical standards are produced under strict quality control to ensure the highest isotopic purity and chemical integrity, which is critical for reliable quantitative analysis. Each batch is characterized using advanced techniques including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically >98 atom % D), chemical purity, and analytical results. We support GMP/GLP-compliant research and can supply materials suitable for regulatory submission support.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.