Description

2-(Boc-Amino)-2-Propenoic Acid is a protected amino acid derivative featuring a tert-butoxycarbonyl (Boc) group, a cornerstone reagent in modern organic synthesis. Its primary value lies in serving as a versatile, chiral building block for the controlled introduction of dehydroalanine units into peptide chains, enabling the synthesis of complex, conformationally constrained molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel peptide-based therapeutics, enzyme inhibitors, and advanced materials.

Application

• Peptide Synthesis: A key precursor for incorporating dehydroalanine residues into peptides, creating structural constraints and enabling "click chemistry" modifications.
• Pharmaceutical Intermediates: Serves as a critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially protease inhibitors and other targeted therapies.
• Bioconjugation & Probe Development: Used to create labeled peptides or protein conjugates for biochemical assays, diagnostic tools, and targeted drug delivery systems.
• Chemical Biology Research: Enables the study of protein-protein interactions and enzyme mechanisms through the site-specific introduction of unsaturated amino acids.
• Material Science: Acts as a monomer or cross-linking agent for developing specialized polymers with unique backbone properties.

Basic Information

Product Name	2-(Boc-Amino)-2-Propenoic Acid
CAS No.	45101-25-5
Molecular Formula	C8H13NO4
Molecular Weight	187.19 g/mol
Synonyms	(Boc-DHA-OH); 2-[(tert-Butoxycarbonyl)amino]acrylic Acid; (Boc-Amino)acrylic Acid; N-Boc-2-aminoacrylic Acid; N-(tert-Butoxycarbonyl)dehydroalanine; Dehydroalanine, N-Boc-; tert-Butyl (1-carboxyvinyl)carbamate; 2-Aminoacrylic acid N-Boc derivative
EINECS	Contact for details

Quality Control

Our 2-(Boc-Amino)-2-Propenoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.