Description

(R)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic Acid is a high-value, chiral trifluoromethylated building block essential for modern synthetic chemistry. Its unique structure, featuring a stereogenic tertiary alcohol center adjacent to a trifluoromethyl group, makes it a critical intermediate for introducing chirality and fluorine into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients, where its properties can enhance metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel Active Pharmaceutical Ingredients (APIs), particularly in antiviral, anti-inflammatory, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with tailored surface properties and stability.
• Fluorine Chemistry Research: A valuable standard and building block in academic and industrial research focused on incorporating fluorinated motifs.

Basic Information

Product Name	(R)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic Acid
CAS No.	44864-47-3
Molecular Formula	C4H5F3O3
Molecular Weight	158.08 g/mol
Synonyms	(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic Acid; (R)-2-Hydroxy-2-methyl-3,3,3-trifluoropropionic Acid; (R)-α-Hydroxy-α-methyl-β,β,β-trifluoropropionic Acid; D-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid; (R)-HMTFP; (R)-TFP Acid; (2R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic Acid
EINECS	Contact for details

Quality Control

Our production of (R)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, potency, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.