Description

(S)-(+)-Neomenthyldiphenylphosphine CAS NO 43077-29-8 is a high-value, chiral organophosphorus ligand characterized by its neomenthyl backbone. This compound matters significantly as a privileged ligand in asymmetric catalysis, enabling the synthesis of enantiomerically pure pharmaceuticals and fine chemicals with high selectivity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as asymmetric hydrogenation and cross-coupling reactions.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the production of enantiomerically enriched intermediates.
• Catalyst component in asymmetric cross-coupling and carbon-carbon bond-forming reactions.
• Key reagent in academic and industrial research for developing novel synthetic methodologies.
• Used in the synthesis of active pharmaceutical ingredients (APIs) requiring high optical purity.
• Application in the preparation of agrochemicals and other specialty fine chemicals where chirality is critical.
• As a precursor or modifier for homogeneous catalyst systems in various transition metal-catalyzed processes.

Basic Information

Product Name	(S)-(+)-Neomenthyldiphenylphosphine
CAS No.	43077-29-8
Molecular Formula	C22H29P
Molecular Weight	324.44 g/mol
Synonyms	(S)-(+)-Neomenthyldiphenylphosphine; (1S,2S,5S)-2-Isopropyl-5-methylcyclohexyl(diphenyl)phosphine; (S)-Neomenthyldiphenylphosphine; (S)-NMDPP; P-((1S,2S,5S)-1-Isopropyl-4-methylcyclohexyl)diphenylphosphine; (1S,2S,5S)-1-Isopropyl-2-methyl-5-(diphenylphosphino)cyclohexane; (S)-(+)-NMDPP; Diphenyl((1S,2S,5S)-2-isopropyl-5-methylcyclohexyl)phosphine
EINECS	Contact for details

Quality Control

Our (S)-(+)-Neomenthyldiphenylphosphine is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes rigorous analytical testing, including chiral HPLC, 31P NMR, and 1H NMR, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (ee)	≥ 98.0%
Melting Point	Contact for details
Specific Rotation [α]D20	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.