Description

4-Iodobut-1-yne is a versatile alkyne building block featuring a terminal iodine substituent, enabling diverse cross-coupling and functionalization reactions. This compound is valued for its role as a key synthetic intermediate in the preparation of complex organic molecules and advanced materials. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds through efficient carbon-carbon bond formation.

Application

4-Iodobut-1-yne serves as a critical reagent in advanced organic synthesis. Its primary applications include:

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: A key building block for creating novel herbicides, fungicides, and plant growth regulators with specific alkyne functionalities.
• Material Science: Employed in the development of polymers, liquid crystals, and organic electronic materials that require conjugated alkyne backbones.
• Chemical Research: Acts as a versatile precursor in academic and industrial R&D for exploring new catalytic cycles and constructing molecular scaffolds.
• Ligand & Catalyst Development: Useful for synthesizing specialized phosphine or N-heterocyclic carbene ligands containing alkyne spacers.

Basic Information

Product Name	4-Iodobut-1-yne
CAS No.	43001-25-8
Molecular Formula	C4H5I
Molecular Weight	179.99 g/mol
Synonyms	1-Iodo-3-butyne; But-3-yn-1-yl iodide; 3-Butyn-1-yl iodide; 4-Iodo-1-butyne; 4-Iodobut-1-yne; 4-Iodobutyne; 1-Butyne, 4-iodo-
EINECS	Contact for details

Quality Control

Our 4-Iodobut-1-yne is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, assay, and impurity profiles. We are committed to meeting the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.