Description

Z-D-Nva-Oh is a protected amino acid derivative, specifically the Z-protected form of D-norvaline. This compound serves as a crucial chiral building block in the synthesis of complex peptides and pharmaceutical intermediates. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-norvaline residue with N-terminal carboxybenzyl (Z) protection.
• Biochemical Research: Employed in studying enzyme-substrate interactions, metabolic pathways, and as a standard in analytical method development.
• Proteomics & Bioconjugation: Acts as a modified amino acid for creating custom peptides used in antibody-drug conjugates (ADCs) and diagnostic probes.
• Fine Chemical Production: A building block for synthesizing specialized compounds requiring the unique properties of the D-norvaline side chain.

Basic Information

Product Name	Z-D-Nva-Oh
CAS No.	42918-89-8
Molecular Formula	C₁₃H₁₇NO₄
Molecular Weight	251.28 g/mol
Synonyms	N-Carbobenzyloxy-D-norvaline; Z-D-Norvaline; (R)-2-(((Benzyloxy)carbonyl)amino)pentanoic acid; D-Norvaline, N-[(phenylmethoxy)carbonyl]-; N-Cbz-D-norvaline; Benzyloxycarbonyl-D-norvaline; (R)-2-((((Benzyloxy)carbonyl)amino)pentanoic acid; N-[(Benzyloxy)carbonyl]-D-norvaline
EINECS	Contact for details

Quality Control

Our Z-D-Nva-Oh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and synthesis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.