Description

n-Phthaloyl-L-Aspartic Acid CAS NO 42406-53-1 is a high-purity, protected amino acid derivative widely used as a key chiral building block in organic synthesis. Its primary value lies in enabling the controlled synthesis of complex peptides and pharmaceutical intermediates while preventing unwanted side reactions at the aspartic acid moiety. This compound is essential for research and production facilities in the pharmaceutical, biotechnology, and fine chemical industries, particularly those developing novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules and peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected L-aspartic acid derivative in solid-phase and solution-phase peptide synthesis to prevent side-chain reactions.
• Chiral Building Block: Used in asymmetric synthesis to introduce chirality and specific functional groups into target molecules with high enantiomeric purity.
• Bioconjugation & Linker Chemistry: Employed in the development of antibody-drug conjugates (ADCs) and other bioconjugates where a protected carboxylic acid group is required.
• Research & Development: A valuable tool for medicinal chemists and researchers in academia and industry for exploring new synthetic pathways and novel chemical entities.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, advanced materials, and catalysts requiring specific amino acid frameworks.

Basic Information

Product Name	n-Phthaloyl-L-Aspartic Acid
CAS No.	42406-53-1
Molecular Formula	C₁₃H₁₁NO₆
Molecular Weight	277.23 g/mol
Synonyms	N-Phthaloyl-L-aspartic acid; (2S)-2-(1,3-Dioxoisoindolin-2-yl)butanedioic acid; L-Aspartic acid, N-phthaloyl-; Phthaloyl-L-aspartic acid; 2-Phthalimidosuccinic acid; N-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-L-aspartic acid; Phth-L-Asp-OH; Pht-L-Asp-OH
EINECS	Contact for details

Quality Control

Our n-Phthaloyl-L-Aspartic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment ensures the material meets the high standards required for pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMF, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.