Description

16 Alpha,18-Dihydroxydeoxycorticosterone is a synthetic corticosteroid derivative with significant research and pharmaceutical development interest. This compound is valued for its role as a key intermediate in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel anti-inflammatory agents, mineralocorticoid receptor modulators, and other therapeutic steroids. The material's defined stereochemistry at the 16-alpha and 18-positions makes it a crucial building block for targeted synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of advanced corticosteroid APIs and investigational new drugs.
• Biochemical Research: Used in laboratory studies to investigate steroid hormone metabolism, receptor binding affinity, and structure-activity relationships (SAR).
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid compounds.
• Development of Mineralocorticoid Antagonists: Acts as a starting material or intermediate for research into new agents targeting conditions like hypertension and heart failure.

Basic Information

Product Name	16 Alpha,18-Dihydroxydeoxycorticosterone
CAS No.	42280-41-1
Molecular Formula	C21H30O5
Molecular Weight	362.46 g/mol
Synonyms	16α,18-Dihydroxy-11-deoxycorticosterone; 16α,18-Dihydroxy-21-hydroxy-4-pregnene-3,20-dione; 11-Deoxy-16α,18-dihydroxycorticosterone; 16α,18-Dihydroxy-DOC; 16α,18-Dihydroxy-11-deoxycorticosterone; 16α,18-Dihydroxy-21-hydroxypregn-4-ene-3,20-dione; 16α,18-Dihydroxy-11-deoxycorticosterone (16α,18-DiOH-DOC)
EINECS	Contact for details

Quality Control

Our 16 Alpha,18-Dihydroxydeoxycorticosterone is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the results for assay, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.