Description

N6-Trifluoroacetyl-L-Lysine n-Carboxyanhydride is a specialized, high-purity amino acid derivative used as a critical building block in peptide synthesis. This compound matters because it enables the controlled, racemization-free incorporation of protected lysine residues, ensuring the structural integrity and biological activity of complex synthetic peptides. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require precise and reliable reagents for constructing peptide-based drugs, diagnostics, and biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the sequential, machine-assisted assembly of long-chain peptides and small proteins.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for synthesizing specific peptide fragments.
• Pharmaceutical Intermediate: Critical for the production of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Bioconjugation and Labeling: Serves as a precursor for introducing functionalized lysine side chains into peptides for attachment of probes, tags, or drug molecules.
• Research & Development: Employed in academic and industrial labs for exploring novel peptide structures, peptidomimetics, and their structure-activity relationships.
• Biomaterial Fabrication: Used in the synthesis of peptide amphiphiles, hydrogels, and other smart materials for biomedical applications.

Basic Information

Product Name	N6-Trifluoroacetyl-L-Lysine n-Carboxyanhydride
CAS No.	42267-27-6
Molecular Formula	C9H11F3N2O4
Molecular Weight	268.19 g/mol
Synonyms	Nε-Trifluoroacetyl-L-lysine NCA; N6-TFA-L-Lysine NCA; (S)-2,5-Dioxo-4-(6-(trifluoroacetamido)hexyl)oxazolidine; TFA-Lys NCA; Nε-Trifluoroacetyl-L-lysine N-Carboxyanhydride; L-Lysine, N6-(trifluoroacetyl)-, N-carboxyanhydride; NCA of Nε-TFA-L-lysine
EINECS	Contact for details

Quality Control

Our N6-Trifluoroacetyl-L-Lysine n-Carboxyanhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP-guided production. Each lot undergoes comprehensive analytical testing including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress. For long-term stability, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous DMF, DMSO, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.