Description

1-(Chloromethyl)-2-(Difluoromethoxy)Benzene is a versatile aromatic building block featuring both a reactive chloromethyl group and a difluoromethoxy substituent. This unique bifunctional structure makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds and agrochemicals, where the introduction of fluorine atoms is a key strategy for modulating biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and antiviral drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances lipophilicity and biological efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or surface properties.
• Cross-Coupling Reactions: The chloromethyl group allows for further functionalization via palladium-catalyzed cross-coupling (e.g., Suzuki, Heck) to create diverse chemical libraries.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring the effects of fluorine substitution in organic molecules.

Basic Information

Product Name	1-(Chloromethyl)-2-(Difluoromethoxy)Benzene
CAS No.	42145-50-6
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	2-(Difluoromethoxy)benzyl Chloride; α-Chloro-2-(difluoromethoxy)toluene; Benzene, 1-(chloromethyl)-2-(difluoromethoxy)-; o-(Difluoromethoxy)benzyl Chloride; 2-(Difluoromethoxy)benzyl Chloride; (2-(Difluoromethoxyphenyl)methyl Chloride; 1-Chloromethyl-2-difluoromethoxy-benzene
EINECS	Contact for details

Quality Control

Our 1-(Chloromethyl)-2-(Difluoromethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.