Description

1-Ethoxy-2,3,5,6-Tetrafluorobenzene is a high-purity fluorinated aromatic ether building block, valued for its unique electronic and steric properties imparted by the tetrafluoro substitution pattern. This compound is essential for advanced chemical synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty materials where precise molecular architecture is critical. It serves as a key intermediate for researchers and manufacturers in fine chemical, pharmaceutical, and electronic chemical industries seeking to introduce fluorinated aromatic motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring fluorinated aromatic rings to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of fluorinated components for liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), improving dielectric anisotropy and electron transport properties.
• Polymer & Specialty Material Modifier: Incorporated into high-performance polymers and coatings to impart enhanced chemical resistance, thermal stability, and low surface energy.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl systems.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new fluorination methodologies and creating novel fluorinated compounds for various applications.

Basic Information

Product Name	1-Ethoxy-2,3,5,6-Tetrafluorobenzene
CAS No.	42099-81-0
Molecular Formula	C8H6F4O
Molecular Weight	194.13 g/mol
Synonyms	2,3,5,6-Tetrafluoro-1-ethoxybenzene; Ethoxy-2,3,5,6-tetrafluorobenzene; 1-Ethoxy-2,3,5,6-tetrafluorobenzene; Benzene, 1-ethoxy-2,3,5,6-tetrafluoro-; 2,3,5,6-Tetrafluorophenyl ethyl ether; Tetrafluoroethoxybenzene
EINECS	Contact for details

Quality Control

Our 1-Ethoxy-2,3,5,6-Tetrafluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including GC, HPLC, and NMR to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We are committed to meeting the stringent requirements of our global customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, strong bases, and strong oxidizing agents. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥98.0%
Water Content (KF)	≤0.5%
Related Substances (GC)	Total impurities ≤2.0%
Density (20°C)	~1.35 g/mL
Refractive Index (n20D)	~1.420

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.