Description

n-Nitroso-D-Proline is a chiral, cyclic nitrosamine derivative of the non-proteinogenic amino acid D-proline. This compound is of significant interest in biochemical and pharmaceutical research, particularly in the study of nitrosation processes and their biological implications. It serves as a critical intermediate and reference standard for scientists in toxicology, analytical chemistry, and medicinal chemistry fields, where precise molecular structure and high purity are paramount.

Application

• Biochemical Research Standard: Used as a high-purity reference material for calibrating analytical instruments (e.g., HPLC, LC-MS) in studies of nitrosamine formation and metabolism.
• Toxicology Studies: Employed as a model nitrosamine compound in research investigating the carcinogenic mechanisms and metabolic pathways of N-nitroso derivatives.
• Pharmaceutical Intermediate: Acts as a specialized chiral building block in the synthesis of complex molecules for drug discovery and development programs.
• Analytical Method Development: Serves as a critical standard for developing and validating sensitive detection methods for nitrosamine impurities in pharmaceuticals and other matrices.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic chemistry, stereochemistry, and reaction mechanisms involving nitrosamines.

Basic Information

Product Name	n-Nitroso-D-Proline
CAS No.	42022-03-7
Molecular Formula	C5H8N2O3
Molecular Weight	144.13 g/mol
Synonyms	D-Proline, N-nitroso-; (R)-1-Nitrosopyrrolidine-2-carboxylic Acid; N-Nitroso-D-proline; N-Nitrosoproline, D-; (-)-N-Nitrosoproline; 42022-03-7; (R)-N-Nitrosoproline
EINECS	Contact for details

Quality Control

Our n-Nitroso-D-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, chiral purity, and related substances. We support compliance with global regulatory frameworks for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consideration should be given to maintaining an inert atmosphere (e.g., under argon or nitrogen) to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.