Description

Naproxen Glucuronide is a major, pharmacologically relevant metabolite of the widely used non-steroidal anti-inflammatory drug (NSAID) naproxen. This compound is critical for research and development in pharmacokinetics, drug metabolism studies, and bioanalytical method validation. It serves as an essential reference standard for pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on anti-inflammatory drug development and safety profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of naproxen metabolites in biological matrices during clinical and non-clinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Used to study the metabolic pathways, clearance rates, and bioavailability of naproxen in vitro and in vivo.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and toxicology assessments.
• Impurity Profiling: Acts as a known impurity or degradation product standard for quality control in naproxen and naproxen sodium drug substance and product manufacturing.
• Enzyme Activity Studies: Utilized in investigations of UDP-glucuronosyltransferase (UGT) enzyme kinetics and polymorphism studies affecting drug glucuronidation.
• Regulatory Submissions: Supports Investigational New Drug (IND) and New Drug Application (NDA) filings by providing definitive characterization of major human metabolites.

Basic Information

Product Name	Naproxen Glucuronide
CAS No.	41945-43-1
Molecular Formula	C22H26O10
Molecular Weight	450.44 g/mol
Synonyms	Naproxen β-D-Glucuronide; (S)-Naproxen Glucuronide; 6-Methoxy-α-methyl-2-naphthaleneacetic acid β-D-glucopyranosiduronic acid; O-{[(2S)-1-(6-Methoxy-2-naphthyl)propan-2-yl]oxy}carbonyl-β-D-glucopyranuronic acid; Naproxen Acyl Glucuronide; Naproxen 1-O-β-Acyl Glucuronide; Naproxen O-Glucuronide; Naproxen metabolite M1
EINECS	Contact for details

Quality Control

Our Naproxen Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identification by NMR and MS, and determination of residual solvents and moisture content to ensure it meets the stringent requirements for use as a reference standard. Certificates of Analysis (COA) with detailed chromatographic data and batch-specific results are provided.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, ideally between 15-25°C (59-77°F), in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.