Description

1-(Chloromethyl)-4-(Difluoromethoxy)Benzene is a versatile aromatic building block featuring both a reactive chloromethyl group and a difluoromethoxy substituent. This unique bifunctional structure makes it a critical intermediate for synthesizing advanced molecules where fluorine incorporation is desired for modulating properties like metabolic stability, lipophilicity, and bioavailability. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, anti-inflammatory, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and as a scaffold for constructing complex fluorinated aromatic systems in academic and industrial R&D.

Basic Information

Product Name	1-(Chloromethyl)-4-(Difluoromethoxy)Benzene
CAS No.	41772-09-2
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	4-(Difluoromethoxy)benzyl Chloride; α-Chloro-4-(difluoromethoxy)toluene; (4-(Difluoromethoxy)phenyl)methyl Chloride; p-(Difluoromethoxy)benzyl Chloride; Benzene, 1-(chloromethyl)-4-(difluoromethoxy)-; DFMB-Cl
EINECS	Contact for details

Quality Control

Every batch of 1-(Chloromethyl)-4-(Difluoromethoxy)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles by validated methods (HPLC, GC, NMR) is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.