Description

2,3-Dihydroxyalclofenac is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) alclofenac. This compound is of significant interest in pharmaceutical research and development, particularly for metabolic studies and the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in drug discovery, pharmacokinetic analysis, and impurity profiling.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis and research of novel anti-inflammatory agents and their derivatives.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods (LC-MS, HPLC) for studying the metabolism and pharmacokinetics of alclofenac.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate the pharmacological activity, toxicity, and metabolic pathways of NSAIDs.
• Impurity Profiling: Essential for the identification and quantification of related substances in alclofenac active pharmaceutical ingredient (API) to ensure drug purity and safety.
• Academic Research: Used in universities and research institutes for medicinal chemistry projects and understanding structure-activity relationships (SAR) of carboxylic acid-based drugs.

Basic Information

Product Name	2,3-Dihydroxyalclofenac
CAS No.	41451-01-8
Molecular Formula	C13H12Cl2O5
Molecular Weight	319.14 g/mol
Synonyms	2,3-Dihydroxy-4-allyloxy-3-chlorobenzeneacetic acid; 2-(2,3-Dihydroxy-4-(allyloxy)-3-chlorophenyl)acetic acid; Alclofenac metabolite; 4-Allyloxy-3-chloro-2,3-dihydroxybenzeneacetic acid; 3-Chloro-2,3-dihydroxy-4-(prop-2-en-1-yloxy)phenylacetic acid
EINECS	Contact for details

Quality Control

Our 2,3-Dihydroxyalclofenac is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.