Description

3-(Difluoromethoxy)Phenylacetonitrile is a versatile fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its unique difluoromethoxy group adjacent to a reactive benzylic nitrile makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the development of fluorinated components for liquid crystal displays (LCDs), contributing to improved dielectric anisotropy and stability.
• Organic Electronic Materials: Employed in the synthesis of novel organic semiconductors and charge-transport materials for applications in OLEDs and organic photovoltaics.
• Custom Synthesis & Contract Research: A valuable starting material for custom synthesis projects and medicinal chemistry programs in academic and industrial R&D laboratories.
• Fluorine Chemistry Research: Used as a model compound or reagent in studies exploring new fluorination methodologies and the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	3-(Difluoromethoxy)Phenylacetonitrile
CAS No.	41429-18-9
Molecular Formula	C9H7F2NO
Molecular Weight	183.16 g/mol
Synonyms	2-[3-(Difluoromethoxy)phenyl]acetonitrile; (3-(Difluoromethoxy)phenyl)acetonitrile; 3-(Difluoromethoxy)benzeneacetonitrile; α-Cyano-3-(difluoromethoxy)toluene; 3-(Difluoromethoxy)benzyl cyanide; DFMPAN; 41429-18-9; Difluoromethoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.