Description

4-(Difluoromethoxy)Phenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the nitrile group and the stability imparted by the difluoromethoxy substituent, enabling the construction of complex molecular architectures. This intermediate is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key precursor for active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs).
• Functional Material Development: Employed in organic synthesis for creating specialty polymers, dyes, and advanced materials with specific electronic or optical properties.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	4-(Difluoromethoxy)Phenylacetonitrile
CAS No.	41429-16-7
Molecular Formula	C9H7F2NO
Molecular Weight	183.15 g/mol
Synonyms	2-[4-(Difluoromethoxy)phenyl]acetonitrile; p-(Difluoromethoxy)phenylacetonitrile; 4-(Difluoromethoxy)benzyl cyanide; (4-(Difluoromethoxy)phenyl)acetonitrile; α-Cyano-4-(difluoromethoxy)toluene; Difluoromethoxyphenylacetonitrile; DFMPAN
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Phenylacetonitrile is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.