Description

Nafcillin Sulfoxide is a key chemical intermediate and degradation product of the β-lactam antibiotic nafcillin. This compound is of significant importance in pharmaceutical research and development, particularly for analytical method development, stability studies, and impurity profiling. It is primarily utilized by research institutions, pharmaceutical manufacturers, and quality control laboratories engaged in the synthesis, analysis, and regulatory compliance of penicillin-based antibiotics.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the identification and quantification of nafcillin and its related substances in drug products and active pharmaceutical ingredients (APIs).
• Impurity Profiling & Analytical Research: Used in method development and validation for HPLC, LC-MS, and other chromatographic techniques to monitor degradation pathways and ensure product purity.
• Stability Studies: Employed as a marker compound in forced degradation studies to understand the stability profile of nafcillin under various stress conditions (e.g., oxidation, hydrolysis).
• Metabolite Research: Investigated in pharmacokinetic and metabolic studies to understand the biotransformation of nafcillin in biological systems.
• Quality Control (QC) & Quality Assurance (QA): Essential for in-house calibration and system suitability testing in pharmaceutical QC laboratories to comply with pharmacopeial standards (USP, EP).
• Academic & Synthetic Chemistry: Used as a building block or model compound in academic research focused on β-lactam chemistry, antibiotic resistance, and novel synthesis routes.

Basic Information

Product Name	Nafcillin Sulfoxide
CAS No.	41061-20-5
Molecular Formula	C21H22N2O6S
Molecular Weight	430.48 g/mol
Synonyms	(2S,5R,6R)-6-[[(2-Ethoxy-1-naphthoyl)amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid S-oxide; Nafcillin S-oxide; Nafcillin sulfoxide; Nafcillin sulfoxide sodium; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, 4-oxide, (2S,5R,6R)-; Nafcillin related compound B
EINECS	Contact for details

Quality Control

Our Nafcillin Sulfoxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for pharmaceutical analysis. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles are provided and can be tailored to support compliance with USP, EP, ICH Q3A/B, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.