Description

L-Proline, D-Alanyl-, Phenylmethyl Ester, Hydrochloride (1:1) is a protected dipeptide derivative, specifically the benzyl ester hydrochloride salt of the D-Ala-L-Pro dipeptide. This compound is a crucial chiral building block and intermediate in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic agents, protease inhibitors, and novel bioactive molecules. Its defined structure and high purity make it essential for advanced medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Used as a building block for creating inhibitors targeting specific proteolytic enzymes.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the design of novel peptidomimetics.
• Bioconjugation & Labeling: Serves as a precursor for preparing peptide conjugates for diagnostic or targeted delivery applications.
• Chemical Biology Probes: Utilized in the synthesis of probes to study enzyme function and protein-protein interactions.
• Process Chemistry & Scale-up: Provides a reliable, high-quality intermediate for pilot-scale and commercial manufacturing processes.

Basic Information

Product Name	L-Proline, D-Alanyl-, Phenylmethyl Ester, Hydrochloride (1:1)
CAS No.	41036-22-0
Molecular Formula	C15H20N2O3 · HCl
Molecular Weight	312.79 g/mol (free base: 276.33 g/mol)
Synonyms	D-Ala-L-Pro-OBzl · HCl; Benzyl D-alanyl-L-prolinate hydrochloride; D-Alanyl-L-proline benzyl ester hydrochloride; H-D-Ala-L-Pro-OBzl · HCl; (S)-1-((R)-2-((Benzyloxy)carbonylamino)propanoyl)pyrrolidine-2-carboxylic acid hydrochloride; Boc-D-Ala-L-Pro-OBzl precursor; Protected D-Ala-L-Pro dipeptide ester HCl salt
EINECS	Contact for details

Quality Control

Our L-Proline, D-Alanyl-, Phenylmethyl Ester, Hydrochloride (1:1) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.