Description

Sodium (6R-Trans)-3-(Acetoxymethyl)-7-Amino-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate is a key sodium salt derivative of a cephalosporin nucleus, serving as a critical advanced pharmaceutical intermediate. Its value lies in providing a stable, reactive platform for the synthesis of semi-synthetic cephalosporin antibiotics, ensuring high-purity inputs for downstream manufacturing. This compound is essential for pharmaceutical R&D laboratories and API manufacturers focused on developing and producing next-generation β-lactam antibiotics to address bacterial resistance.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a high-purity building block in the chemical synthesis of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Serves as a crucial intermediate in medicinal chemistry for creating novel antibiotic candidates and studying structure-activity relationships.
• Process Chemistry & Scale-Up: Used in pilot plants and commercial manufacturing to develop efficient, scalable routes for antibiotic production.
• Reference Standard: Can be utilized as a chromatographic or spectroscopic standard for quality control and analytical method development in pharmaceutical analysis.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized or proprietary cephalosporin derivatives.

Basic Information

Product Name	Sodium (6R-Trans)-3-(Acetoxymethyl)-7-Amino-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
CAS No.	40994-22-7
Molecular Formula	C11H12N3NaO5S
Molecular Weight	321.28 g/mol
Synonyms	7-Aminocephalosporanic Acid Sodium Salt (7-ACA Sodium Salt); Sodium 7-Amino-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 7-ACA Na; (6R,7R)-3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt; Sodium 7-ACA; 7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Acetate (Ester) Sodium Salt; Cephalosporanic Acid Derivative Sodium Salt
EINECS	Contact for details

Quality Control

Our Sodium 7-ACA is manufactured under strict quality management systems, with purity and identity verified through modern analytical techniques. We ensure compliance with pharmaceutical-grade standards, and a comprehensive Certificate of Analysis (COA) detailing assay, related substances, residual solvents, and microbiological data is provided with each batch to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
pH (10% solution)	6.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.