Description

5,7-Dichloro-8-Quinolinol Glucuronide is a key conjugated metabolite of the antimicrobial agent clioquinol, formed via glucuronidation. This compound is of significant importance for research and development in pharmaceutical analysis and metabolism studies. It serves as a critical reference standard for laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors, enabling precise quantification and metabolic pathway elucidation.

Application

• Pharmaceutical Reference Standard: Primary use as a high-purity certified standard for analytical method development and validation in drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolite Identification & Quantification: Essential for identifying and quantifying the glucuronidated metabolite of clioquinol in biological matrices (e.g., plasma, urine) using LC-MS/MS or HPLC.
• Toxicology & Safety Assessment: Used in research to understand the metabolic fate, bioavailability, and potential toxicity profile of the parent drug compound.
• Biochemical Research: Employed in studies investigating phase II metabolism (glucuronidation) enzymes (UGTs) and drug-drug interaction potentials.
• Quality Control in Manufacturing: Acts as a critical quality attribute marker in the production and batch release of the active pharmaceutical ingredient (API) where relevant.

Basic Information

Product Name	5,7-Dichloro-8-Quinolinol Glucuronide
CAS No.	40951-47-1
Molecular Formula	C₁₅H₁₃Cl₂NO₇
Molecular Weight	390.17 g/mol
Synonyms	5,7-Dichloro-8-hydroxyquinoline glucuronide; Clioquinol Glucuronide; 8-Quinolinol, 5,7-dichloro-, 1-(β-D-glucopyranosiduronic acid); 5,7-Dichloro-8-quinolyl β-D-glucopyranosiduronic acid; 5,7-Dichloro-8-quinolinol β-D-glucuronide; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(5,7-dichloro-8-quinolyloxy)oxane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5,7-Dichloro-8-Quinolinol Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data (HPLC purity, related substances) and spectroscopic confirmation (MS, NMR). Our quality commitment aligns with the standards expected for high-grade reference materials in pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing at -20°C under inert atmosphere. Keep the container in a dry, well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Related Substances (HPLC)	≤5.0% total
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.