Description

(5S)-5-Aminopyrrolidin-2-One is a high-purity chiral building block and intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a key precursor for the synthesis of various pharmacologically active compounds, particularly those targeting the central nervous system. This product is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for advanced drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the production of nootropic agents, cognitive enhancers, and other neurologically active pharmaceuticals.
• API Synthesis: Serves as a key building block in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs), especially those containing the pyrrolidinone scaffold.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce chiral centers into complex molecular architectures.
• Bioconjugation & Linker Chemistry: The primary amine and lactam functionalities make it suitable for creating peptide mimetics or specialized chemical linkers.
• Agrochemical Research: Used in the development of novel, enantiomerically pure pesticides and herbicides.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and process development in fine chemical synthesis.

Basic Information

Product Name	(5S)-5-Aminopyrrolidin-2-One
CAS No.	40759-90-8
Molecular Formula	C₄H₈N₂O
Molecular Weight	100.12 g/mol
Synonyms	(S)-5-Aminopyrrolidin-2-one; (S)-5-Amino-2-pyrrolidinone; L-5-Aminopyrrolidin-2-one; (S)-2-Oxo-5-pyrrolidineamine; (5S)-5-Amino-2-oxopyrrolidine; (S)-5-Amino-dihydro-2(3H)-furanone (tautomer); (S)-Aminopyrrolidinone; (S)-5-AP
EINECS	Contact for details

Quality Control

Our (5S)-5-Aminopyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.