Description

Angiotensin II, 5-L-Isoleucine-8-Glycine- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II. This modified sequence is critical for research into the renin-angiotensin system (RAS), a key regulator of blood pressure and fluid balance. It is an essential biochemical tool for pharmaceutical R&D, academic research, and diagnostic development, enabling studies on receptor binding, signal transduction, and the pathophysiology of cardiovascular and renal diseases.

Application

• Biomedical Research: Fundamental studies on the structure-activity relationships (SAR) of Angiotensin II receptor (AT1 & AT2) ligands.
• Pharmaceutical Development: Used as a reference standard or intermediate in the discovery and development of novel antihypertensive drugs and cardiovascular therapeutics.
• Biochemical Assays: Serves as a specific agonist or substrate in enzyme-linked immunosorbent assays (ELISA), radioimmunoassays (RIA), and other in vitro diagnostic test systems.
• Signal Transduction Studies: Investigation of G-protein coupled receptor (GPCR) mechanisms and intracellular calcium mobilization pathways.
• Academic & Clinical Research: Exploration of the role of the RAS in hypertension, heart failure, kidney disease, and metabolic disorders.
• Quality Control: Acts as a high-purity reference material for calibrating analytical instruments and validating methods in QC laboratories.

Basic Information

Product Name	Angiotensin II, 5-L-Isoleucine-8-Glycine-
CAS No.	40678-47-5
Molecular Formula	C₄₉H₆₉N₁₃O₁₂
Molecular Weight	1032.2 g/mol
Synonyms	[Ile5, Gly8]-Angiotensin II; Angiotensin II (5-Ile, 8-Gly); Asp-Arg-Val-Tyr-Ile-His-Pro-Gly; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Gly-OH; Saralasin Acetate analog; ATII analog; [Gly8]-Angiotensin II
EINECS	Contact for details

Quality Control

Our Angiotensin II, 5-L-Isoleucine-8-Glycine- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, peptide content, and solvent residues. Our quality commitment ensures material suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.