Description

D-His-Protirelin is a synthetic, biologically active peptide analog of the endogenous thyrotropin-releasing hormone (TRH). This high-purity compound is critical for advanced pharmaceutical research and development, particularly in neuroendocrinology and diagnostic applications. It is primarily utilized by research institutions, pharmaceutical companies, and diagnostic manufacturers requiring precise and reliable peptide standards for their work.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and assay calibration in drug manufacturing.
• Biomedical Research: Used in neuroendocrine studies to investigate TRH receptor interactions, signal transduction, and hormone regulation.
• Diagnostic Agent Development: Employed in the research and production of diagnostic kits for assessing pituitary and thyroid function.
• Peptide Chemistry Studies: Acts as a model compound in methodological development for peptide synthesis, purification, and analysis.
• Preclinical Investigations: Utilized in animal studies to explore potential therapeutic applications for neurological disorders.

Basic Information

Product Name	D-His-Protirelin
CAS No.	40600-90-6
Molecular Formula	C16H22N6O4
Molecular Weight	362.39 g/mol
Synonyms	D-His-TRH; D-Histidyl-Prolineamide; (R)-5-Oxo-L-prolyl-L-histidyl-L-prolinamide; D-His-Pro-NH2; D-Histidyl-Proline Amide; TRH (D-His analog); Thyrotropin-Releasing Hormone, D-His-; Pyroglutamyl-D-histidyl-prolinamide
EINECS	Contact for details

Quality Control

Our D-His-Protirelin CAS NO 40600-90-6 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (D-His isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.