Description

n-Boc-Amino-(3-Thienyl)Acetic Acid is a high-purity, protected amino acid derivative featuring a thiophene side chain, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of a heterocyclic moiety into peptide backbones and complex molecules, which is essential for modulating biological activity and physicochemical properties. This compound is particularly vital for research chemists and process development scientists in the pharmaceutical and biotechnology industries engaged in creating novel therapeutic agents, especially within peptide mimetics and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate a thienylglycine residue, enhancing peptide stability and bioactivity.
• Protease Inhibitor Development: Serves as a core scaffold or side-chain component in the design of enzyme inhibitors targeting various proteases.
• Bioconjugation & Labeling: The Boc-protected amino group and carboxylic acid functionality allow for selective conjugation to biomolecules, proteins, or fluorescent tags.
• Material Science Research: Employed in the synthesis of functionalized polymers or organic semiconductors that incorporate heterocyclic units for electronic applications.
• Chemical Biology Probes: Utilized to create tool compounds and molecular probes for studying biological pathways and protein function.

Basic Information

Product Name	n-Boc-Amino-(3-Thienyl)Acetic Acid
CAS No.	40512-57-0
Molecular Formula	C11H15NO4S
Molecular Weight	257.30 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-2-(3-thienyl)acetic acid; Boc-3-Thienylglycine; (3-Thienyl)-N-Boc-glycine; tert-Butyl (3-thienylglycyl)carbamate; N-(tert-Butoxycarbonyl)-3-thienylglycine; 2-((tert-Butoxycarbonyl)amino)-2-(thiophen-3-yl)acetic acid; Boc-Thienylglycine-OH; 40512-57-0
EINECS	Contact for details

Quality Control

Our n-Boc-Amino-(3-Thienyl)Acetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) providing full specifications and test results is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.