Description

Dihydromorphine-3-Glucuronide is a key glucuronide metabolite of dihydromorphine, a semi-synthetic opioid analgesic. This compound is of significant importance in pharmaceutical research and forensic toxicology for studying opioid metabolism, pharmacokinetics, and developing analytical reference standards. It is primarily needed by research institutions, pharmaceutical development laboratories, and forensic science organizations engaged in advanced metabolite identification and quantification studies.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative analysis of dihydromorphine and its metabolites in biological matrices.
• Metabolite Research: Used in in vitro and in vivo studies to understand the metabolic pathways, clearance rates, and active/inactive metabolite profiles of opioid pharmaceuticals.
• Forensic Toxicology: Essential for the development and validation of highly sensitive analytical methods (LC-MS/MS, GC-MS) for the accurate detection of opioid use in forensic and workplace drug testing.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Employed to establish concentration-effect relationships and to model the distribution and elimination of dihydromorphine.
• Clinical Trial Support: Utilized in bioanalytical laboratories supporting clinical trials for opioid-based medications to monitor metabolite levels and ensure patient safety.
• Quality Control in Drug Manufacturing: Acts as a purity standard for ensuring the consistency and quality of related pharmaceutical active ingredients and finished products.

Basic Information

Product Name	Dihydromorphine-3-Glucuronide
CAS No.	40505-77-9
Molecular Formula	C23H29NO9
Molecular Weight	463.48 g/mol
Synonyms	Dihydromorphine 3-β-D-Glucuronide; Dihydromorphine-3-O-β-D-Glucuronide; 3-Glucuronide of Dihydromorphine; Dihydromorphine Glucuronide; 4,5α-Epoxy-3-hydroxy-17-methylmorphinan-6-one 3-β-D-Glucuronide; Paramorfan glucuronide; Paramorphan glucuronide
EINECS	Contact for details

Quality Control

Our Dihydromorphine-3-Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and reference applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.