Description

2-Iodophenylacetonitrile is a versatile halogenated aromatic nitrile compound, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic positioning of the iodine atom and the reactive nitrile group, enabling efficient cross-coupling reactions and functional group transformations. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with complex aryl-iodide coupling sites.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators that require halogenated aromatic structures.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and advanced polymers where the iodine moiety facilitates further functionalization.
• Cross-Coupling Reactions: Essential substrate for palladium-catalyzed reactions such as Suzuki-Miyaura, Heck, and Sonogashira couplings to form new carbon-carbon bonds.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Intermediate in the multi-step synthesis of dyes, pigments, and other high-value specialty chemicals.

Basic Information

Product Name	2-Iodophenylacetonitrile
CAS No.	40400-15-5
Molecular Formula	C8H6IN
Molecular Weight	243.05 g/mol
Synonyms	(2-Iodophenyl)acetonitrile; 2-Iodobenzyl cyanide; α-Cyano-2-iodotoluene; o-Iodophenylacetonitrile; 2-Iodobenzeneacetonitrile; (o-Iodophenyl)acetonitrile; 40400-15-5; NSC 404087
EINECS	Contact for details

Quality Control

Our 2-Iodophenylacetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.