Description

Pamidronic Acid is a second-generation bisphosphonate compound, a class of drugs known for their potent ability to inhibit bone resorption. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacturing of effective treatments for bone disorders. It is primarily utilized by pharmaceutical companies and research institutions focused on osteoporosis, Paget's disease, and hypercalcemia of malignancy. Our supply of Pamidronic Acid CAS NO 40391-99-9 ensures the stringent quality and reliability required for advanced therapeutic applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for treating osteoporosis and bone metastases.
• Oncological Treatments: Manufacture of medications to manage hypercalcemia (high blood calcium levels) associated with various cancers.
• Metabolic Bone Disease Therapy: Key component in drugs for Paget's disease of bone and other conditions involving excessive bone turnover.
• Research & Development: Serves as a critical reference standard and building block in pharmacological and biochemical research on bone metabolism.
• Veterinary Medicine: Potential application in developing treatments for bone disorders in animals.
• Formulation Development: Used in pre-formulation studies and the development of novel drug delivery systems for bisphosphonates.

Basic Information

Product Name	Pamidronic Acid
CAS No.	40391-99-9
Molecular Formula	C3H11NO7P2
Molecular Weight	235.09 g/mol
Synonyms	Pamidronate; APD; (3-Amino-1-hydroxypropylidene)bisphosphonic acid; Aminohydroxypropylidene bisphosphonate; Pamidronate Disodium (salt form); CGP-23339; Aredia (brand name derivative); 3-Amino-1-hydroxypropane-1,1-diyldiphosphonic acid
EINECS	254-904-1

Quality Control

Our Pamidronic Acid is manufactured under strict quality systems to meet the exacting standards of the pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC. We provide full traceability and support regulatory submissions with comprehensive documentation. A Certificate of Analysis (COA) is supplied with every shipment, detailing compliance with in-house specifications aligned with major pharmacopoeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.