Description

Butanenitrile, 3-Methyl-2-[(Trimethylsilyl)Oxy]- is a specialized organosilicon-protected cyanohydrin derivative, a key synthetic intermediate in advanced organic synthesis. This compound matters for its role as a protected form of a cyanohydrin, offering enhanced stability and controlled reactivity for the construction of complex chiral molecules. Pharmaceutical, agrochemical, and fine chemical R&D laboratories need it for the precise synthesis of active pharmaceutical ingredients (APIs), natural products, and other high-value targets.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of chiral drugs, particularly those containing nitrile and hydroxyl functionalities.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Manufacturing: Serves as a versatile precursor for flavors, fragrances, and other specialty chemicals requiring high purity intermediates.
• Academic & Industrial Research: A valuable reagent in methodological development for asymmetric synthesis and new reaction pathway exploration.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or functional materials with tailored properties.

Basic Information

Product Name	Butanenitrile, 3-Methyl-2-[(Trimethylsilyl)Oxy]-
CAS No.	40326-16-7
Molecular Formula	C8H17NOSi
Molecular Weight	171.31 g/mol
Synonyms	3-Methyl-2-[(trimethylsilyl)oxy]butanenitrile; (Trimethylsilyloxy)isovaleronitrile; 2-Isopropyl-2-(trimethylsilyloxy)acetonitrile; O-Trimethylsilyl-3-hydroxy-3-methylbutyronitrile; TMS-protected cyanohydrin of isobutyraldehyde; 3-Hydroxy-3-methylbutyronitrile TMS ether; 2-(Trimethylsiloxy)-3-methylbutyronitrile
EINECS	Contact for details

Quality Control

Our Butanenitrile, 3-Methyl-2-[(Trimethylsilyl)Oxy]- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including GC, HPLC, and NMR spectroscopy. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.