Description

Lidocaine Hydrochloride, [Carbonyl-14C] is a carbon-14 radiolabeled derivative of the widely used local anesthetic and antiarrhythmic agent, lidocaine hydrochloride. This isotopically labeled compound is an essential tool for conducting advanced pharmacokinetic, metabolic, and drug disposition studies, providing critical data on absorption, distribution, metabolism, and excretion (ADME). It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in drug development and safety assessment.

Application

• ADME (Absorption, Distribution, Metabolism, Excretion) Studies: Tracing the metabolic fate and pharmacokinetic profile of lidocaine and related compounds in biological systems.
• Drug Metabolism Research: Identifying and quantifying metabolites to understand biotransformation pathways and potential drug-drug interactions.
• Pharmacokinetic Modeling: Providing precise quantitative data for developing and validating PK/PD (pharmacokinetic/pharmacodynamic) models.
• Bioanalytical Method Development: Serving as an internal standard or reference material in LC-MS/MS and other sensitive analytical techniques.
• Toxicology and Safety Assessment: Investigating tissue distribution and long-term retention of lidocaine or its metabolites in preclinical studies.
• Mechanistic Studies: Elucidating the precise mechanisms of action and transport of lidocaine at the molecular level.

Basic Information

Product Name	Lidocaine Hydrochloride, [Carbonyl-14C]
CAS No.	40252-00-4
Molecular Formula	C14H22N2O • HCl (with 14C at the carbonyl carbon)
Molecular Weight	270.80 g/mol (unlabeled base)
Synonyms	2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide Hydrochloride, [carbonyl-14C]; Lignocaine Hydrochloride-14C; Xylocaine Hydrochloride-14C; [Carbonyl-14C]-Lidocaine HCl; 14C-Lidocaine Hydrochloride; Lidocaine-14C HCl; α-Diethylamino-2,6-acetoxylidide Hydrochloride-14C
EINECS	Contact for details

Quality Control

Our radiolabeled compounds are manufactured and controlled under a strict quality management system. Each batch is characterized to ensure high radiochemical purity and chemical purity, with specific activity and stability verified. Comprehensive Certificates of Analysis (COA) are provided, detailing results for assay, radiochemical purity (by HPLC or TLC), specific activity, and solvent content. Our quality commitment supports compliance with standards required for GLP (Good Laboratory Practice) and non-clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container sealed under an inert atmosphere in a dedicated freezer. Users must handle this material in accordance with all local and national regulations for radioactive substances.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.