Description

1-((Trimethylsilyl)Ethynyl)-4-Trifluoro is a specialized organosilicon building block featuring both a protected acetylene (ethynyl) group and a trifluoromethyl substituent. This unique molecular architecture makes it a high-value intermediate for synthesizing complex molecules where precise structural control and fluorination are critical. It is primarily utilized by pharmaceutical and agrochemical research organizations for the development of new active ingredients, as well as in advanced materials science for creating functionalized polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly where fluorine atoms are introduced to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the trifluoromethyl group for enhanced biological activity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and liquid crystalline materials with tailored properties.
• Organic Synthesis Reagent: Employed in Sonogashira coupling and other palladium-catalyzed reactions to introduce alkynyl-silyl functional groups into complex molecular frameworks.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring the effects of fluorination on molecular properties and reactivity.

Basic Information

Product Name	1-((Trimethylsilyl)Ethynyl)-4-Trifluoro
CAS No.	40230-95-3
Molecular Formula	C8H11F3Si
Molecular Weight	192.26 g/mol
Synonyms	1-(Trimethylsilylethynyl)-4-(trifluoromethyl)benzene; 4-(Trifluoromethyl)phenyl(trimethylsilyl)acetylene; p-(Trifluoromethyl)phenyl(trimethylsilyl)acetylene; 1-Ethynyl-4-(trifluoromethyl)benzene trimethylsilyl derivative; TMS-Ethynyl-4-Trifluoromethylbenzene; 1-((Trimethylsilyl)ethynyl)-4-(trifluoromethyl)benzene; 4-(Trimethylsilylethynyl)benzotrifluoride
EINECS	Contact for details

Quality Control

Our production of 1-((Trimethylsilyl)Ethynyl)-4-Trifluoro adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.