Description

1-((Trimethylsilyl)Ethynyl)-3-Trifluoro is a specialized organosilicon building block featuring both a reactive ethynyl group and a trifluoromethyl substituent. This compound is valued for its role in advanced organic synthesis, particularly in the construction of complex molecules for pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for applications in cross-coupling reactions and as a precursor to fluorinated scaffolds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated or silicon-based moieties.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or precursor in the development of advanced polymers, coatings, and organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group acts as a versatile handle for Sonogashira, Glaser, and other metal-catalyzed coupling reactions to form conjugated systems.
• Fluorine Chemistry: An essential reagent for introducing the CF3 group into complex organic molecules under mild conditions.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-((Trimethylsilyl)Ethynyl)-3-Trifluoro
CAS No.	40230-93-1
Molecular Formula	C8H11F3Si
Molecular Weight	192.26 g/mol
Synonyms	3-(Trimethylsilylethynyl)benzotrifluoride; 1-Ethynyl-3-(trifluoromethyl)benzene, trimethylsilyl derivative; 1-((Trimethylsilyl)ethynyl)-3-(trifluoromethyl)benzene; m-(Trimethylsilylethynyl)benzotrifluoride; 3-(Trifluoromethyl)phenylethynyltrimethylsilane; TMS-Ethynyl Trifluorotoluene Derivative; (3-(Trifluoromethyl)phenyl)ethynyltrimethylsilane
EINECS	Contact for details

Quality Control

Our production of 1-((Trimethylsilyl)Ethynyl)-3-Trifluoro adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed via GC, HPLC, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.