Description

Phe-Gly-Gly-Phe CAS NO 40204-87-3 is a synthetic tetrapeptide composed of phenylalanine and glycine residues. This compound serves as a crucial research-grade biochemical building block and a model substrate for enzymatic studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in peptide chemistry and protease mechanism analysis.

Application

• Biochemical Research: Used as a model substrate for studying the kinetics and specificity of proteolytic enzymes like chymotrypsin and elastase.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the synthesis and analysis of more complex therapeutic peptides.
• Enzyme Assay Kits: Incorporated into commercial and in-house assay kits to measure protease activity and screen for enzyme inhibitors.
• Academic Studies: Employed in university laboratories for teaching and research in biochemistry, enzymology, and medicinal chemistry.
• Peptide Library Synthesis: Acts as a core sequence or spacer in the construction of combinatorial peptide libraries for drug discovery.
• Quality Control: Functions as a purity standard and system suitability marker in analytical methods (e.g., HPLC) for peptide-based products.

Basic Information

Product Name	Phe-Gly-Gly-Phe
CAS No.	40204-87-3
Molecular Formula	C24H28N4O5
Molecular Weight	452.51 g/mol
Synonyms	FGGG; Phenylalanylglycylglycylphenylalanine; L-Phenylalanyl-glycyl-glycyl-L-phenylalanine; Tetrapeptide F-G-G-F; Glycine, L-phenylalanylglycylglycyl-L-phenylalanine; H-Phe-Gly-Gly-Phe-OH; N-(N-(N-L-Phenylalanylglycyl)glycyl)-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Phe-Gly-Gly-Phe is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research specifications. Our quality system is designed to meet the rigorous demands of GMP/GLP-aligned research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.