Description

H-cis-Hyp-Ome Hcl CAS NO 40126-30-5 is a protected derivative of the amino acid hydroxyproline, specifically the cis isomer of methyl 4-hydroxyprolinate hydrochloride. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of peptide-based pharmaceuticals and bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, stereochemically defined intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide drugs, protease inhibitors, and collagenase inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified hydroxyproline residues.
• Medicinal Chemistry Research: Serves as a building block for creating novel drug candidates and molecular probes targeting various diseases.
• Bioconjugation: Utilized in the preparation of peptide-drug conjugates (PDCs) and other bioconjugates due to its reactive ester group.
• Chemical Biology: Employed in the study of collagen structure and function, as well as in developing enzyme substrates or inhibitors.
• Fine Chemical Synthesis: Intermediate for the production of more complex, stereospecific organic molecules.

Basic Information

Product Name	H-cis-Hyp-Ome Hcl
CAS No.	40126-30-5
Molecular Formula	C6H12ClNO3
Molecular Weight	181.62 g/mol
Synonyms	(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride; Methyl cis-4-hydroxy-L-prolinate hydrochloride; L-Hydroxyproline methyl ester hydrochloride (cis isomer); cis-4-Hydroxy-L-proline methyl ester HCl; H-cis-Hyp-OMe·HCl; (4R)-Hydroxy-L-proline methyl ester hydrochloride; 40126-30-5; Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our H-cis-Hyp-Ome Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically >98%), and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (cis isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.