Description

17β-Estradiol 3-o-Sulfate Sodium Salt is a high-purity, water-soluble sulfated conjugate of the primary female sex hormone. This compound is a critical reference standard and biochemical tool for research and development in endocrinology and pharmaceutical sciences. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries requiring precise analytical standards for hormone metabolism studies, assay development, and quality control.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of estradiol metabolites in drug development and bioequivalence studies.
• Clinical Research & Diagnostics: Serves as a critical calibrator and control in the development and validation of immunoassays (ELISA, RIA) and LC-MS/MS methods for measuring hormone levels in biological samples.
• Biochemical Research: Employed in studies of estrogen sulfotransferase enzyme activity, hormone conjugation pathways, and the role of sulfated steroids in cellular signaling and metabolism.
• Metabolite Identification: A key analyte for the identification and quantification of Phase II estrogen metabolites in pharmacokinetic and toxicological research.
• Quality Control: Used by API manufacturers to ensure the purity and consistency of related steroid products and metabolites.

Basic Information

Product Name	17β-Estradiol 3-o-Sulfate Sodium Salt
CAS No.	4999-79-5
Molecular Formula	C18H23NaO5S
Molecular Weight	374.42 g/mol
Synonyms	Estradiol 3-Sulfate Sodium Salt; Sodium Estradiol Sulfate; E2-3S Sodium Salt; 17β-Estradiol 3-Sulfate Sodium; Estra-1,3,5(10)-triene-3,17β-diol 3-sulfate sodium salt; NSC 124403; 17β-Oestradiol 3-sulphate sodium salt; Sodium 17β-estradiol 3-sulfate
EINECS	225-662-6

Quality Control

Our 17β-Estradiol 3-o-Sulfate Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports your need for reliable and consistent reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric humidity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.