Description

4-Methoxytetrafluorobenzyl Bromide is a high-value fluorinated aromatic building block used in advanced organic synthesis. This compound is critical for introducing the 4-methoxy-2,3,5,6-tetrafluorobenzyl moiety, a key structural motif that imparts unique electronic and steric properties to target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorinated benzyl group enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving performance and durability.
• Cross-Coupling Reactions: An effective electrophile in Suzuki-Miyaura, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Protecting Group Chemistry: The benzyl bromide functionality can be used for the protection of alcohols, phenols, and carboxylic acids in multi-step syntheses.
• Material Science Research: Employed in the creation of fluorinated polymers and specialty coatings with enhanced chemical resistance and surface properties.

Basic Information

Product Name	4-Methoxytetrafluorobenzyl Bromide
CAS No.	4910-40-1
Molecular Formula	C8H5BrF4O
Molecular Weight	273.02 g/mol
Synonyms	1-(Bromomethyl)-2,3,5,6-tetrafluoro-4-methoxybenzene; 2,3,5,6-Tetrafluoro-4-methoxybenzyl Bromide; 4-Methoxy-2,3,5,6-tetrafluorobenzyl Bromide; α-Bromo-2,3,5,6-tetrafluoro-4-methoxytoluene; p-Methoxytetrafluorobenzyl Bromide
EINECS	Contact for details

Quality Control

Every batch of 4-Methoxytetrafluorobenzyl Bromide is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.