Description

1-Benzyl-5-Fluorouracil is a fluorinated pyrimidine derivative, a key intermediate in the synthesis of more complex nucleoside analogs and active pharmaceutical ingredients (APIs). This compound matters for its role in medicinal chemistry research, particularly in developing novel antiviral and anticancer agents. Pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in nucleoside chemistry require this high-purity building block for their synthetic programs.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel fluorinated nucleoside analogs and prodrugs with potential antiviral or antitumor activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to modify the uracil scaffold for enhanced biological activity and selectivity.
• Biochemical Probe Development: Serves as a precursor for labeled compounds used to study enzyme mechanisms, particularly those involving thymidylate synthase or other pyrimidine metabolism pathways.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce the benzyl-protected fluorouracil moiety into more complex molecular architectures.
• Academic & Industrial R&D: A valuable reagent for universities and contract research organizations (CROs) exploring new chemical entities in the fluoropyrimidine class.

Basic Information

Product Name	1-Benzyl-5-Fluorouracil
CAS No.	4871-13-0
Molecular Formula	C11H9FN2O2
Molecular Weight	220.20 g/mol
Synonyms	5-Fluoro-1-benzyluracil; 1-Benzyl-5-fluoropyrimidine-2,4(1H,3H)-dione; N1-Benzyl-5-fluorouracil; 5-Fluoro-1-(phenylmethyl)uracil; 1-Benzyl-5-fluoro-2,4(1H,3H)-pyrimidinedione; Benzyl-5-fluorouracil; N-Benzyl-5-fluorouracil
EINECS	Contact for details

Quality Control

Our 1-Benzyl-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.