Description

Z-Leu-Nh2 CAS NO 4801-79-0 is a protected amino acid derivative, specifically the benzyloxycarbonyl (Z or Cbz)-protected form of leucine amide. This compound serves as a crucial high-purity building block in peptide synthesis and pharmaceutical research, where protecting group strategy is essential for controlling reaction specificity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers involved in developing novel therapeutic peptides and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the controlled incorporation of leucine residues.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex peptide sequences and natural products.
• Pharmaceutical Intermediate: For the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: As a substrate or inhibitor in enzymatic studies and proteomics research.
• Combinatorial Chemistry: A valuable building block for generating diverse chemical libraries for drug discovery screening.
• Custom Synthesis: Serves as a starting material for the preparation of more complex, specialized amino acid derivatives and conjugates.

Basic Information

Item	Detail
Product Name	Z-Leu-Nh2
CAS No.	4801-79-0
Molecular Formula	C₁₄H₂₀N₂O₃
Molecular Weight	264.32 g/mol
Synonyms	N-Carbobenzyloxy-L-leucinamide; Cbz-L-Leucinamide; Z-L-Leucinamide; (S)-2-(((Benzyloxy)carbonyl)amino)-4-methylpentanamide; Benzyl N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]carbamate; Nα-Cbz-L-leucinamide; Leucine, N-[(phenylmethoxy)carbonyl]-, amide, L-; N-Carbobenzoxy-L-leucinamide
EINECS	Contact for details

Quality Control

Our Z-Leu-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation to ensure it meets the stringent requirements for research and synthesis applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.