Description

(3R,4S)-4,5-Isopropylidene-Pent-2-Yn-3-Ol is a high-purity chiral building block featuring a protected diol and an alkyne functionality. This compound matters as a versatile synthetic intermediate, enabling the stereoselective construction of complex molecular architectures in pharmaceutical and fine chemical synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Synthesis of chiral pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• Building block for natural product synthesis and complex molecule construction.
• Precursor in the development of agrochemicals and specialty fine chemicals.
• Intermediate for materials science applications, including ligand and polymer synthesis.
• Use in asymmetric synthesis and catalysis research.
• Starting material for the preparation of advanced diagnostic reagents.

Basic Information

Product Name	(3R,4S)-4,5-Isopropylidene-Pent-2-Yn-3-Ol
CAS No.	4688-38-4
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	(3R,4S)-4,5-O-Isopropylidene-2-pentyn-1,4-diol; (3R,4S)-4,5-O-Isopropylidene-2-pentyn-4-ol; (3R,4S)-4,5-Isopropylidene-2-pentyn-1,4-diol; (3R-cis)-4,5-O-(1-Methylethylidene)-2-pentyn-1,4-diol; (3R,4S)-4,5-O-(1-Methylethylidene)-2-pentyn-1,4-diol; 2-Pentyn-1,4-diol, 4,5-O-(1-methylethylidene)-, (3R,4S)-
EINECS	Contact for details

Quality Control

Our (3R,4S)-4,5-Isopropylidene-Pent-2-Yn-3-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and process chemistry. Certificates of Analysis (COA) with full specification data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.