Description

Estriol 3-Sulfate 16-Glucuronide is a specific, double-conjugated metabolite of the endogenous estrogen, estriol. This compound is of significant value as a high-purity reference standard and a critical intermediate in biochemical research and diagnostic development. It is primarily required by pharmaceutical R&D laboratories, clinical diagnostics manufacturers, and academic institutions focused on endocrinology and steroid metabolism studies.

Application

• Biochemical Reference Standard: Used as a certified reference material (CRM) for the calibration of analytical instruments in quantitative assays.
• Diagnostic Kit Development: Serves as a key antigen or calibrator in the development of immunoassays for measuring estrogen metabolites in clinical samples.
• Metabolic Pathway Research: Essential for in vitro and in vivo studies investigating the phase II conjugation and elimination pathways of estrogens.
• Pharmaceutical Impurity Profiling: Employed as an impurity marker in the quality control of estrogen-based pharmaceutical products.
• Mass Spectrometry Internal Standard: Utilized as a stable-isotope labeled analog (when deuterated or 13C-labeled) for precise LC-MS/MS quantification in metabolomics.
• Enzyme Activity Studies: Acts as a substrate for studying the activity of sulfatases and glucuronidases involved in hormone regulation.

Basic Information

Product Name	Estriol 3-Sulfate 16-Glucuronide
CAS No.	4661-65-8
Molecular Formula	C24H32O13S
Molecular Weight	560.57 g/mol
Synonyms	Estriol 3-Sulfate 16-Glucuronide; E3-3S-16G; 16α-Hydroxyestriol 3-Sulfate 16-Glucuronide; Estriol 3-Sulphate 16-Glucuronide; 1,3,5(10)-Estratrien-3,16α,17β-triol 3-Sulfate 16-Glucuronide; Estriol 16-Glucuronide 3-Sulfate; NSC 113986
EINECS	Contact for details

Quality Control

Our Estriol 3-Sulfate 16-Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, MS), to ensure it meets the stringent requirements for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.