Description

4-Chlorobenzoylacetonitrile is a versatile organic intermediate characterized by its reactive nitrile and carbonyl functional groups. This compound matters for its role as a key building block in the synthesis of heterocyclic compounds and complex organic molecules. It is primarily needed by the pharmaceutical, agrochemical, and specialty chemical industries for research and development, as well as process-scale manufacturing.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with benzodiazepine or pyrazole backbones.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, leveraging its chlorinated aromatic structure.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in coordination chemistry and catalytic processes.
• Organic Synthesis Building Block: Employed in Knoevenagel condensations and cyclization reactions to construct complex heterocyclic systems like pyrimidines and pyridines.
• Material Science Research: Investigated as a monomer or additive in the development of advanced polymers and functional materials.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and organic pigments due to its reactive sites.

Basic Information

Product Name	4-Chlorobenzoylacetonitrile
CAS No.	4640-66-8
Molecular Formula	C9H6ClNO
Molecular Weight	179.60 g/mol
Synonyms	4-Chlorobenzoylacetonitrile; 3-Oxo-3-(4-chlorophenyl)propanenitrile; 4-Chloro-ω-cyanacetophenone; (4-Chlorobenzoyl)acetonitrile; 4-Chlorobenzeneacetyl cyanide; 1-(4-Chlorophenyl)-3-oxopropanenitrile; p-Chlorobenzoylacetonitrile; 3-(4-Chlorophenyl)-3-oxopropanenitrile
EINECS	225-063-3

Quality Control

Our 4-Chlorobenzoylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable, ensuring reliability for critical pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The compound may be moisture-sensitive; ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92°C - 96°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.