Description

2-Trifluoromethyl-Adenosine is a high-purity, modified nucleoside building block of significant interest in advanced pharmaceutical and biochemical research. This compound matters for its role as a key synthetic intermediate in the development of novel therapeutics, particularly antiviral agents and enzyme inhibitors, where the trifluoromethyl group can dramatically alter biological activity and metabolic stability. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and prodrug development.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating enzyme-substrate interactions, nucleotide metabolism, and the structure-activity relationships (SAR) of modified nucleosides.
• Prodrug Development: Serves as a precursor for prodrug strategies aimed at improving the bioavailability and targeting of therapeutic nucleosides.
• Medicinal Chemistry: Employed in lead optimization and library synthesis for drug discovery programs targeting viral polymerases and other nucleoside-binding proteins.
• Reference Standard: Utilized as an analytical standard in quality control and method development for pharmaceutical manufacturing.

Basic Information

Product Name	2-Trifluoromethyl-Adenosine
CAS No.	4627-40-1
Molecular Formula	C11H12F3N5O4
Molecular Weight	335.24 g/mol
Synonyms	2-(Trifluoromethyl)adenosine; 9-β-D-Ribofuranosyl-2-(trifluoromethyl)adenine; Adenosine, 2-(trifluoromethyl)-; 2-CF3-Adenosine; 2-Trifluoromethyl-9-β-D-ribofuranosyladenine; 2-Trifluoromethyladenosine; 2-TFM-Ado
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-Adenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications. We support cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.